Immunological Sciences

NDR1/2 (Phospho-Thr444/442) Rabbit Polyclonal Antibody

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Catalog Number:ABN05817
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:Synthesized peptide derived from human NDR1/2 (Phospho-Thr444/442)
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000
Molecular Weight:51kDa
Purification:Affinity purification
Form:Liquid
Synonyms:Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)

Applications

WB 1:500-1:2000

Immunogen

Synthesized peptide derived from human NDR1/2 (Phospho-Thr444/442)

Target Background

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Low levels present in the cytoplasm.,subunit:Homodimeric S100B binds two molecules of STK38. Interacts with MOB1 and MOB2.,tissue specificity:Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.,

Synonyms:Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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