Immunological Sciences

Neutrophil Elastase Rabbit Monoclonal Antibody

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Catalog Number:MABN86709
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Neutrophil Elastase
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:1000-1:5000,ICC/IF 1:50-1:100,FC 1:20-1:50
Molecular Weight:Calculated MW:29 kDa; Observed MW:29 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:GE; NE; HLE; HNE; ELA2; SCN1; PMN-E

Applications

WB 1:1000-1:5000,IHC 1:1000-1:5000,ICC/IF 1:50-1:100,FC 1:20-1:50

Immunogen

A synthetic peptide of human Neutrophil Elastase

Target Background

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]

Synonyms:GE; NE; HLE; HNE; ELA2; SCN1; PMN-E

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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