NMDAR1 (5R10) Rabbit Monoclonal Antibody
Western blot detection of NMDAR1 in Rat brain,Jurkat cell lysates using NMDAR1 antibody(1:1000 diluted).
| Catalog Number: | MABN14756 |
| Conjugate: | Unconjugated |
| Size: | 100ul |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Clone: | 5R10 |
| Immunogen: | A synthetic peptide of human NMDAR1 |
| Reactivity: | Human,Mouse,Rat |
| Applications: | WB 1:1000-1:2000,ICC/IF 1:20-1:50 |
| Molecular Weight: | 105kDa |
| Purification: | Affinity purification |
| Form: | liquid |
| Synonyms: | GluN1; NMD-R1; GRIN1; NMDAR1 |
N-methyl-D-aspartate receptor (NMDAR) forms a heterodimer of at least one NR1 and one NR2A-D subunit. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits. Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).
Applications
WB 1:1000-1:2000,ICC/IF 1:20-1:50
Immunogen
A synthetic peptide of human NMDAR1