NMDAR2B Rabbit Monoclonal Antibody

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Catalog Number:MABN86655
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of mouse NMDAR2B
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000
Molecular Weight:Calculated MW:166 kDa; Observed MW:166 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:NR2B; GluN2B; Nmdar2b; AW490526

Applications

WB 1:500-1:2000

Immunogen

A synthetic peptide of mouse NMDAR2B

Target Background

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.

Synonyms:NR2B; GluN2B; Nmdar2b; AW490526

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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