Immunological Sciences

NOLC1 Rabbit Monoclonal Antibody

No images available

Catalog Number:MABN85865
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human NOLC1
Reactivity:Human
Applications:WB 1:500-1:1000,IHC 1:50-1:100,ICC 1:50-1:200
Molecular Weight:Calculated MW: 74 kDa; Observed MW: 110 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:P130; NOPP130; NOPP140; NS5ATP13

Applications

WB 1:500-1:1000,IHC 1:50-1:100,ICC 1:50-1:200

Immunogen

A synthetic peptide of human NOLC1

Target Background

Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).

Synonyms:P130; NOPP130; NOPP140; NS5ATP13

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

No documents available.