Notch 1 Rabbit Monoclonal Antibody

No images available

Catalog Number:MABN83723
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human Notch 1
Reactivity:Human,Mouse
Applications:WB 1:1000-1:2000,IHC 1:100-1:200,ICC/IF 1:50-1:200,ICC 1:50-1:200,FC 1:20-1:100
Molecular Weight:Calculated MW: 273 kDa ; Observed MW: 125 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:NOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor,;Notch 1

Applications

WB 1:1000-1:2000,IHC 1:100-1:200,ICC/IF 1:50-1:200,ICC 1:50-1:200,FC 1:20-1:100

Immunogen

A synthesized peptide derived from human Notch 1

Target Background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

Synonyms:NOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor,;Notch 1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

No documents available.