Immunological Sciences

NOTCH4 (18Z4) Rabbit Monoclonal Antibody

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Catalog Number:MABN14808
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human NOTCH4
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IP 1:50-1:100
Molecular Weight:210kDa
Purification:Affinity purification
Form:Liquid
Synonyms:NOTC4; hNotch4; INT3; Notch homolog 4;

Applications

WB 1:500-1:2000,IP 1:50-1:100

Immunogen

Recombinant protein of human NOTCH4

Target Background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).

Synonyms:NOTC4; hNotch4; INT3; Notch homolog 4;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

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