Notch4 Rabbit Monoclonal Antibody

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Catalog Number:MABN02831
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human NOTCH4
Reactivity:Human
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 210 kDa; Observed MW: 36 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:NOTCH4; INT3; Neurogenic locus notch homolog protein 4; Notch 4; hNotch4

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human NOTCH4

Target Background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).

Synonyms:NOTCH4; INT3; Neurogenic locus notch homolog protein 4; Notch 4; hNotch4

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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