NUMB Rabbit Monoclonal Antibody

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Catalog Number:MABN83902
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human NUMB
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:2000
Molecular Weight:71 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:c14_5527; h Numb; Numb; Numb homolog; S171; ;NUMB

Applications

WB 1:1000-1:2000

Immunogen

A synthesized peptide derived from human NUMB

Target Background

Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch. The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates. The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling.

Synonyms:c14_5527; h Numb; Numb; Numb homolog; S171; ;NUMB

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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