OLIG2 Mouse Monoclonal Antibody
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
| Catalog Number: | MABN80950 |
| Conjugate: | Unconjugated |
| Size: | 100ul |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | Mouse IgG1 |
| Clone: | Monoclonal |
| Immunogen: | Purified recombinant fragment of human OLIG2 expressed in E. Coli. |
| Reactivity: | Human |
| Applications: | IHC 1:200-1:1000,ICC 1:200-1:1000,ELISA 1:5000-1:20000 |
| Molecular Weight: | 32kDa |
| Purification: | Affinity purification |
| Form: | liquid |
| Synonyms: | BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19; OLIG2 |
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
Applications
IHC 1:200-1:1000,ICC 1:200-1:1000,ELISA 1:5000-1:20000
Immunogen
Purified recombinant fragment of human OLIG2 expressed in E. Coli.
