p16 INK (16J3) Rabbit Monoclonal Antibody

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Catalog Number:MABN15577
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human CDKN2A/p16INK4a
Reactivity:Human
Applications:WB 1:500-1:2000,IHC 1:50-1:200,FC 1:200-1:500,IP 1:20-1:50,IF-P 1:50-1:200
Molecular Weight:17kDa
Purification:Affinity purification
Form:Liquid
Synonyms:CDKN2A; CDKN2; MTS1; isoforms 1/2/3; Cyclin-dependent kinase 4 inhibitor A; CDK4I; P16INK4; p16INK4a; Multiple tumor suppressor 1;

Applications

WB 1:500-1:2000,IHC 1:50-1:200,FC 1:200-1:500,IP 1:20-1:50,IF-P 1:50-1:200

Immunogen

A synthetic peptide of human CDKN2A/p16INK4a

Target Background

p16-INK4A a cell-cycle regulatory protein that Interacts with CDK4 and CDK6, inhibiting their ability to interact with cyclins D. Inhibits the phosphorylation of the retinoblastoma protein by CDK4 or CDK6. Four alternatively spliced isoforms have been reported. Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

Synonyms:CDKN2A; CDKN2; MTS1; isoforms 1/2/3; Cyclin-dependent kinase 4 inhibitor A; CDK4I; P16INK4; p16INK4a; Multiple tumor suppressor 1;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

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