Immunological Sciences

p53 (acetyl K382) (17F2) Rabbit Monoclonal Antibody

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Catalog Number:MABN15643
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic acetyl-peptide corresponding to residues surrounding Lys9 of human p53
Reactivity:Human
Applications:WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:20-1:50
Molecular Weight:53kDa
Purification:Affinity purification
Form:Liquid
Synonyms:Antigen NY-CO-13, Cellular tumor antigen p53, Phosphoprotein p53, TP53, Tumor suppressor p53

Applications

WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:20-1:50

Immunogen

A synthetic acetyl-peptide corresponding to residues surrounding Lys9 of human p53

Target Background

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Synonyms:Antigen NY-CO-13, Cellular tumor antigen p53, Phosphoprotein p53, TP53, Tumor suppressor p53

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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