Immunological Sciences

p63 (3J16) Rabbit Monoclonal Antibody

No images available

Catalog Number:MABN15659
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human p63
Reactivity:Human
Applications:WB 1:500-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:20-1:50
Molecular Weight:77kDa
Purification:Affinity purification
Form:Liquid
Synonyms:EEC3; KET; LMS; SHFM4; TA p63 alpha; TP63; p51; p73H; p73L; tumor protein p63;

Applications

WB 1:500-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:20-1:50

Immunogen

A synthetic peptide of human p63

Target Background

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Synonyms:EEC3; KET; LMS; SHFM4; TA p63 alpha; TP63; p51; p73H; p73L; tumor protein p63;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

No documents available.