Immunological Sciences

PARP Mouse Mouse Monoclonal Antibody

No images available

Catalog Number:MABN86157
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:IgG
Clone:Monoclonal
Reactivity:Human
Applications:WB 1:1000-1:3000
Molecular Weight:116kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:COBA2; COL11A2; Collagen alpha-2(XI) chain; collagen, type XI, alpha 2; DFNA13

Applications

WB 1:1000-1:3000

Target Background

Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.

Synonyms:COBA2; COL11A2; Collagen alpha-2(XI) chain; collagen, type XI, alpha 2; DFNA13

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

No documents available.