Immunological Sciences

PARP1

Coptisine induces apoptosis in human hepatoma cells through activating 67-kDa laminin receptor/cGMP signaling. Frontiers in pharmacology

Coptisine induces apoptosis in human hepatoma cells through activating 67-kDa laminin receptor/cGMP signaling. Frontiers in pharmacology

Catalog Number:AB-83632
Conjugate:Unconjugated
Size:100 ug
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:POLY
Immunogen:Synthesized peptide derived from the Internal region of human PARP- 1.
Reactivity:Hu,Ms,Rt
Applications:Western Blot : 1/500 - 1/2000 Immunohistochemistry (paraffin-embedded) : 1/50-1/200
Molecular Weight:110KDa
Purification:The antibody was affinity- purified from rabbit antiserum by affinity- chromatography using epitope- specific immunogen.
Form:Liquid
Synonyms:PARP1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; PARP- 1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly [ADP-ribose] synthase 1

Applications

Western Blot : 1/500 - 1/2000 Immunohistochemistry (paraffin-embedded) : 1/50-1/200

Immunogen

Synthesized peptide derived from the Internal region of human PARP- 1.

Target Background

This gene encodes a chromatin-associated enzyme, poly( ADP- ribosyl) transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation,proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Synonyms:PARP1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; PARP- 1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly [ADP-ribose] synthase 1

Storage

Store at -20°C. Avoid repeated freeze-thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Coptisine induces apoptosis in human hepatoma cells through activating 67-kDa laminin receptor/cGMP signaling. Frontiers in pharmacology

Immunohistochemical analysis of paraffin-embedded human brain. 1, Tris-EDTA,pH9.0 was used for antigen retrieval. 2 ,Antibody was diluted at 1:200(4° overnight. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).

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