PDK4 Rabbit Monoclonal Antibody

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Catalog Number:MABN86479
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of mouse PDK4
Reactivity:Mouse,Rat
Applications:WB 1:500-1:2000,FC 1:50-1:100,IP 1:20-1:50
Molecular Weight:Calculated MW:47 kDa; Observed MW:47 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:AV005916

Applications

WB 1:500-1:2000,FC 1:50-1:100,IP 1:20-1:50

Immunogen

Recombinant protein of mouse PDK4

Target Background

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation.

Synonyms:AV005916

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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