Immunological Sciences

Pellino 1 Rabbit Monoclonal Antibody

No images available

Catalog Number:MABN02420
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human Pellino 1
Reactivity:Human,Rat
Applications:WB 1:500-1:1000,IP 1:20-1:50
Molecular Weight:Calculated MW: 46 kDa; Observed MW: 46 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1

Applications

WB 1:500-1:1000,IP 1:20-1:50

Immunogen

Recombinant protein of human Pellino 1

Target Background

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).

Synonyms:Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

No documents available.