Immunological Sciences

Perforin Rabbit Polyclonal Antibody

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Catalog Number:ABN00479
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500
Reactivity:Human
Applications:WB 1:500-1:1000,IHC 1:50-1:100,ELISA 1:5000-1:20000
Molecular Weight:Calculated MW: 61 kDa; Observed MW: 61 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Perforin-1; P1; Cytolysin; Lymphocyte pore-forming protein; PFP

Applications

WB 1:500-1:1000,IHC 1:50-1:100,ELISA 1:5000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500

Target Background

The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Synonyms:Perforin-1; P1; Cytolysin; Lymphocyte pore-forming protein; PFP

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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