Phospho-AKT1 (Thr450) Rabbit Monoclonal Antibody

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Catalog Number:MABN84887
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Thr450 of human AKT1
Reactivity:Human,Rat
Applications:WB 1:500-1:1000,IP 1:10-1:20
Molecular Weight:Calculated MW: 56 kDa; Observed MW: 56 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha

Applications

WB 1:500-1:1000,IP 1:10-1:20

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Thr450 of human AKT1

Target Background

Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473.

Synonyms:AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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