Immunological Sciences

Phospho-Bad (S112) (4M2) Rabbit Monoclonal Antibody

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Catalog Number:MABN05858
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Ser112 of human Bad
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,IP 1:20-1:50
Molecular Weight:18kDa
Purification:Affinity purification
Form:Liquid
Synonyms:BAD; BBC2; BBC6; BCL2L8;

Applications

WB 1:1000-1:5000,IP 1:20-1:50

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser112 of human Bad

Target Background

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Synonyms:BAD; BBC2; BBC6; BCL2L8;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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