Phospho-c-Myc (T58) (1A2) Rabbit Monoclonal Antibody

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Catalog Number:MABN05880
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Thr58 of human c-Myc
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:200-1:1000
Molecular Weight:49kDa
Purification:Affinity purification
Form:Liquid
Synonyms:MRTL; MYC; Myc proto-oncogene protein; c-myc;

Applications

WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:200-1:1000

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Thr58 of human c-Myc

Target Background

Myc a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes. Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).

Synonyms:MRTL; MYC; Myc proto-oncogene protein; c-myc;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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