Immunological Sciences

Phospho-Chk1 (Ser280) Rabbit Monoclonal Antibody

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Catalog Number:MABN87433
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Ser280 of human Chk1
Reactivity:Human
Applications:WB 1:1000-1:5000
Molecular Weight:Calculated MW:54 kDa; Observed MW:54 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CHK1

Applications

WB 1:1000-1:5000

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser280 of human Chk1

Target Background

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Synonyms:CHK1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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