Immunological Sciences

Phospho-ErbB2 (Y1139) (12W6) Rabbit Monoclonal Antibody

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Catalog Number:MABN05898
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Tyr1139 of human ErbB 2
Reactivity:Human
Applications:WB 1:500-1:2000,IP 1:20-1:50
Molecular Weight:138kDa
Purification:Affinity purification
Form:Liquid
Synonyms:CD340; CerbB2; ERBB2; HER2; Herstatin; MLN19; NEU; NGL; p185erbB2; TKR1;

Applications

WB 1:500-1:2000,IP 1:20-1:50

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Tyr1139 of human ErbB 2

Target Background

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Synonyms:CD340; CerbB2; ERBB2; HER2; Herstatin; MLN19; NEU; NGL; p185erbB2; TKR1;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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