Immunological Sciences

Phospho-ErbB3 (Y1222) (11E17) Rabbit Monoclonal Antibody

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Catalog Number:MABN05900
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Tyr1222 of human ErbB 3
Reactivity:Human
Applications:WB 1:1000-1:5000
Molecular Weight:148kDa
Purification:Affinity purification
Form:Liquid
Synonyms:ERBB3; HER3; LCCS2; p180 ErbB3; p45 sErbB3; p85 sErbB3;

Applications

WB 1:1000-1:5000

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Tyr1222 of human ErbB 3

Target Background

Binds and is activated by neuregulins and NTAK. Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).

Synonyms:ERBB3; HER3; LCCS2; p180 ErbB3; p45 sErbB3; p85 sErbB3;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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