Immunological Sciences

Phospho-HDAC5 (Ser498) Rabbit Polyclonal Antibody

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Catalog Number:ABN00916
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:A synthetic Phosphorylated peptide corresponding to residues target protein
Reactivity:Human,Mouse
Applications:WB 1:500-1:1000,IHC 1:50-1:100
Molecular Weight:Calculated MW: 122 kDa; Observed MW: 122 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:HD5; NY-CO-9

Applications

WB 1:500-1:1000,IHC 1:50-1:100

Immunogen

A synthetic Phosphorylated peptide corresponding to residues target protein

Target Background

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Synonyms:HD5; NY-CO-9

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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