Phospho-JAK1 (Y1034 + Y1035) (14S9) Rabbit Monoclonal Antibody

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Catalog Number:MABN05929
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Tyr1022/Tyr1023 of human JAK1
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:50-1:100,IF-P 1:50-1:100
Molecular Weight:133kDa
Purification:Affinity purification
Form:Liquid
Synonyms:JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; JTK3; historically have been referenced as Tyr1022 and Tyr1023 (Y1022 + Y1023);

Applications

WB 1:1000-1:5000,IHC 1:50-1:100,IF-P 1:50-1:100

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Tyr1022/Tyr1023 of human JAK1

Target Background

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333).

Synonyms:JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; JTK3; historically have been referenced as Tyr1022 and Tyr1023 (Y1022 + Y1023);

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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