Immunological Sciences

Phospho-Leptin Receptor (Tyr1141) Rabbit Polyclonal Antibody

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Catalog Number:ABN00943
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:A synthetic Phosphorylated peptide corresponding to residues target protein
Reactivity:Human,Mouse
Applications:WB 1:500-1:1000,ELISA 1:5000-1:20000
Molecular Weight:Calculated MW: 132 kDa; Observed MW: 132 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Leptin receptor; LEP-R; HuB219 OB receptor; OB-R; CD295; LEPR; DB; OBR

Applications

WB 1:500-1:1000,ELISA 1:5000-1:20000

Immunogen

A synthetic Phosphorylated peptide corresponding to residues target protein

Target Background

On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity).

Synonyms:Leptin receptor; LEP-R; HuB219 OB receptor; OB-R; CD295; LEPR; DB; OBR

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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