Phospho-mTOR (S2481) (4Y3) Rabbit Monoclonal Antibody

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Catalog Number:MABN05951
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Ser2448 of human mTOR
Reactivity:Human,Mouse
Applications:WB 1:500-1:2000,IHC 1:20-1:100,IF-P 1:20-1:50
Molecular Weight:289kDa
Purification:Affinity purification
Form:Liquid
Synonyms:FRAP; FRAP1; FRAP2; RAFT1; Rapamycin target protein; kinase mTOR;

Applications

WB 1:500-1:2000,IHC 1:20-1:100,IF-P 1:20-1:50

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser2448 of human mTOR

Target Background

An atypical kinase belonging to the PIKK family of kinases. Controls cell growth through protein synthesis regulation. Downstream of PI3K/Akt pathway and required for cell survival. Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals

Synonyms:FRAP; FRAP1; FRAP2; RAFT1; Rapamycin target protein; kinase mTOR;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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