Immunological Sciences

Phospho-Nucleophosmin (Thr95) Rabbit Monoclonal Antibody

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Catalog Number:MABN87442
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Thr95 of human Nucleophosmin
Reactivity:Human
Applications:WB 1:1000-1:5000
Molecular Weight:Calculated MW:33 kDa; Observed MW:38 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:B23; NPM

Applications

WB 1:1000-1:5000

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Thr95 of human Nucleophosmin

Target Background

The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]

Synonyms:B23; NPM

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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