Immunological Sciences

Phospho-p53 (Ser392) Rabbit Monoclonal Antibody

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Catalog Number:MABN86502
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Ser392 of human p53
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:100-1:200
Molecular Weight:Calculated MW:44 kDa; Observed MW:53 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:P53; BCC7; LFS1; TRP53

Applications

WB 1:1000-1:5000,IHC 1:100-1:200

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser392 of human p53

Target Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Synonyms:P53; BCC7; LFS1; TRP53

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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