Immunological Sciences

Phospho-p53 (T18)

Western blot analysis of extracts from MDA cells, using phospho-TP53-T18 antibody.

Western blot analysis of extracts from MDA cells, using phospho-TP53-T18 antibody.

Catalog Number:ABP-0464
Conjugate:Unconjugated
Size:100 ug
Concentration:1mg/ml
Host:Rb
Isotype:IgG
Clone:Poly
Immunogen:A phospho specific peptide corresponding to residues surrounding T18 of human TP53.
Reactivity:Hu, Ms, Rt
Applications:Western blotting 1:1000
Molecular Weight:53 kDa
Purification:Affinity purification
Form:liquid

Applications

Western blotting 1:1000

Immunogen

A phospho specific peptide corresponding to residues surrounding T18 of human TP53.

Target Background

This gene encodes a tumor suppressor protein containing transcriptional activation,DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

Storage

Store at –20°C. Avoid freeze / thaw cycles.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.4

Western blot analysis of extracts from MDA cells, using phospho-TP53-T18 antibody.

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