Immunological Sciences

Phospho-PAK4 (Ser474)/PAK5 (Ser602)/PAK6 (Ser560) Rabbit Monoclonal Antibody

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Catalog Number:MABN87682
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Ser474 of human PAK4
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,FC 1:200-1:1000
Molecular Weight:Calculated MW:64,81,75 kDa; Observed MW:72,82,90 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Phospho-PAK4 (Ser474)/PAK5 (Ser602)/PAK6 (Ser560) Rabbit Monoclonal Antibody

Applications

WB 1:1000-1:5000,FC 1:200-1:1000

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser474 of human PAK4

Target Background

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Synonyms:Phospho-PAK4 (Ser474)/PAK5 (Ser602)/PAK6 (Ser560) Rabbit Monoclonal Antibody

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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