Phospho-Phospholamban (Ser16) Rabbit Monoclonal Antibody

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Catalog Number:MABN84873
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Ser16 of human Phospholamban
Reactivity:Human,Mouse
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 6 kDa; Observed MW: 12,24 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:PLN; PLB; Cardiac phospholamban; PLB

Applications

WB 1:500-1:1000

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser16 of human Phospholamban

Target Background

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Synonyms:PLN; PLB; Cardiac phospholamban; PLB

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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