Immunological Sciences

Phospho-Rb (Ser807) Rabbit Monoclonal Antibody

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Catalog Number:MABN87447
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Ser807 of human Rb
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:200-1:500,ICC/IF 1:200-1:500
Molecular Weight:Calculated MW:106 kDa; Observed MW:110 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:RB; pRb; OSRC; pp110; p105-Rb; PPP1R130

Applications

WB 1:500-1:2000,IHC 1:200-1:500,ICC/IF 1:200-1:500

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser807 of human Rb

Target Background

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Synonyms:RB; pRb; OSRC; pp110; p105-Rb; PPP1R130

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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