Immunological Sciences

Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Rabbit Monoclonal Antibody

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Catalog Number:MABN84919
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Ser181 of human TAOK1
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000,IHC 1:50-1:100
Molecular Weight:Calculated MW: 116 kDa; Observed MW: 105,116,138 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:DPK; JIK; hKFC-A; MAP3K18

Applications

WB 1:500-1:1000,IHC 1:50-1:100

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser181 of human TAOK1

Target Background

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6.

Synonyms:DPK; JIK; hKFC-A; MAP3K18

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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