Immunological Sciences

Phospho-TIFA (Thr9) Rabbit Monoclonal Antibody

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Catalog Number:MABN87618
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic phosphopeptide corresponding to residues surrounding Thr9 of human TIFA
Reactivity:Human
Applications:WB 1:500-1:2000,IP 1:20-1:50
Molecular Weight:Calculated MW:21 kDa; Observed MW:21 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:T2BP; T6BP; TIFAA

Applications

WB 1:500-1:2000,IP 1:20-1:50

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Thr9 of human TIFA

Target Background

This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018]

Synonyms:T2BP; T6BP; TIFAA

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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