Immunological Sciences

PHOX2B Rabbit Monoclonal Antibody

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Catalog Number:MABN86694
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human PHOX2B
Reactivity:Human,Mouse
Applications:WB 1:500-1:2000,IHC 1:200-1:1000,ICC/IF 1:100-1:200
Molecular Weight:Calculated MW:32 kDa; Observed MW:37 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:PMX2B; NBLST2; NBPhox

Applications

WB 1:500-1:2000,IHC 1:200-1:1000,ICC/IF 1:100-1:200

Immunogen

A synthetic peptide of human PHOX2B

Target Background

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]

Synonyms:PMX2B; NBLST2; NBPhox

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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