Immunological Sciences

PINCH (3C12) Mouse Monoclonal Antibody

No images available

Catalog Number:MABN00862
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:IgG1
Clone:Monoclonal
Reactivity:Human
Applications:WB 1:500-1:1000,ICC/IF 1:50-1:200,FC 1:50-1:100,IP 1:20-1:50
Molecular Weight:Calculated MW: 37 kDa; Observed MW: 37 kDa
Purification:Ascitic Fluid
Form:Liquid
Synonyms:LIMS1; PINCH; PINCH1; LIM and senescent cell antigen-like-containing domain protein 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48

Applications

WB 1:500-1:1000,ICC/IF 1:50-1:200,FC 1:50-1:100,IP 1:20-1:50

Target Background

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms:LIMS1; PINCH; PINCH1; LIM and senescent cell antigen-like-containing domain protein 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

No documents available.