Immunological Sciences

PKD1 Rat Monoclonal Antibody

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Catalog Number:AMR81426
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rat
Isotype:Rat IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of mouse PKD1 (AA: 3682-3873) expressed in E. Coli.
Reactivity:Human
Applications:ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:466kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:PC1; Mflj00285

Applications

ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of mouse PKD1 (AA: 3682-3873) expressed in E. Coli.

Target Background

Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.

Synonyms:PC1; Mflj00285

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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