PKN1 Rabbit Monoclonal Antibody

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Catalog Number:MABN02452
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide corresponding to target protein
Reactivity:Rat
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 104 kDa; Observed MW: 120 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide corresponding to target protein

Target Background

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Synonyms:DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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