PLAT (12E12) Rabbit Monoclonal Antibody

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Catalog Number:MABN16244
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human TPA Tissue Plasminogen Activator
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,IHC 1:100-1:1000,IF-P 1:100-1:1000
Molecular Weight:63kDa
Purification:Affinity purification
Form:Liquid
Synonyms:TPA; T-PA; TPA1; PLAT; Tissue plasminogen activator;

Applications

WB 1:1000-1:5000,IHC 1:100-1:1000,IF-P 1:100-1:1000

Immunogen

A synthetic peptide of human TPA Tissue Plasminogen Activator

Target Background

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity).

Synonyms:TPA; T-PA; TPA1; PLAT; Tissue plasminogen activator;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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