PMS2 Rabbit Monoclonal Antibody

No images available

Catalog Number:MABN85182
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human PMS2
Reactivity:Human
Applications:WB 1:500-1:1000,IP 1:10-1:20
Molecular Weight:Calculated MW: 96 kDa; Observed MW: 96 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2

Applications

WB 1:500-1:1000,IP 1:10-1:20

Immunogen

A synthetic peptide of human PMS2

Target Background

Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.

Synonyms:DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

No documents available.