Immunological Sciences

PPP4C Rabbit Monoclonal Antibody

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Catalog Number:MABN87146
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human PPP4C
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:50-1:200,FC 1:200-1:500
Molecular Weight:Calculated MW:35 kDa; Observed MW:35 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:PP4; PPX; PP-X; PP4C; PPH3; PPP4

Applications

WB 1:500-1:2000,IHC 1:50-1:200,FC 1:200-1:500

Immunogen

Recombinant protein of human PPP4C

Target Background

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair.

Synonyms:PP4; PPX; PP-X; PP4C; PPH3; PPP4

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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