Immunological Sciences

PRC Rabbit Polyclonal Antibody

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Catalog Number:ABN16461
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human PPRC1. AA range:1609-1658
Reactivity:Human,Mouse
Applications:IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:20000-1:40000
Purification:Affinity purification
Form:Liquid
Synonyms:PPRC1; KIAA0595; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; PGC-1-related coactivator; PRC

Applications

IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:20000-1:40000

Immunogen

The antiserum was produced against synthesized peptide derived from human PPRC1. AA range:1609-1658

Target Background

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],function:Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.,induction:Up-regulated by serum (at protein level).,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Colocalizes with NRF1.,subunit:Interacts with CREB1 and NRF1.,tissue specificity:Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.,

Synonyms:PPRC1; KIAA0595; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; PGC-1-related coactivator; PRC

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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