Proteinase 3 Mouse Monoclonal Antibody

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Catalog Number:MABN80762
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG2b
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
Reactivity:Human,Mouse
Applications:ICC 1:50-1:200,ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:28kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:PRTN3; ACPA; CANCA

Applications

ICC 1:50-1:200,ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.

Target Background

Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

Synonyms:PRTN3; ACPA; CANCA

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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