PSD95 (13H1) Rabbit Monoclonal Antibody
Western blot analysis of extracts from Mouse brain tissue using RM4408 at 1:1000.
| Catalog Number: | MABN16592 |
| Conjugate: | Unconjugated |
| Size: | 100ul |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Clone: | 13H1 |
| Immunogen: | Recombinant protein of human PSD95 |
| Reactivity: | Human,Mouse,Rat |
| Applications: | WB 1:500-1:2000,IHC 1:50-1:200,IP 1:20-1:50,IF-P 1:50-1:200 |
| Molecular Weight: | 81kDa |
| Purification: | Affinity purification |
| Form: | liquid |
| Synonyms: | DLG4; Disks large homolog 4; PSD95; SAP90; Synapse associated protein 90; |
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.
Applications
WB 1:500-1:2000,IHC 1:50-1:200,IP 1:20-1:50,IF-P 1:50-1:200
Immunogen
Recombinant protein of human PSD95