PTP1B (13P19) Rabbit Monoclonal Antibody

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Catalog Number:MABN16665
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human PTP1B
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:200-1:1000,IP 1:20-1:50,IF-P 1:200-1:1000
Molecular Weight:50kDa
Purification:Affinity purification
Form:Liquid
Synonyms:CPTP1; PTN1; PTP-1B; PTP-HA2; PTPN1;

Applications

WB 1:500-1:2000,IHC 1:200-1:1000,IP 1:20-1:50,IF-P 1:200-1:1000

Immunogen

A synthetic peptide of human PTP1B

Target Background

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c- src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Synonyms:CPTP1; PTN1; PTP-1B; PTP-HA2; PTPN1;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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