Immunological Sciences

PUMA Rabbit Monoclonal Antibody

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Catalog Number:MABN21276
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG,Kappa
Clone:Monoclonal
Immunogen:A synthetic peptide of human PUMA
Reactivity:Human,Mouse,Rat,
Applications:WB 1:2000-1:10000,IHC 1:500-1:2000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200
Molecular Weight:CalcuLated MW:21kD;Observed MW:21kD
Purification:Protein A
Form:Liquid
Synonyms:BBC3;PUMA;Bcl-2-binding component 3;JFY-1;p53 up-reguLated moduLator of apoptosis

Applications

WB 1:2000-1:10000,IHC 1:500-1:2000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200

Immunogen

A synthetic peptide of human PUMA

Target Background

Cell localization:Mitochondrion.This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],

Synonyms:BBC3;PUMA;Bcl-2-binding component 3;JFY-1;p53 up-reguLated moduLator of apoptosis

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

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