Immunological Sciences

Purified Anti-Human CD27 Antibody[O323]

Human peripheral blood lymphocytes were stained with 0.2 μg Purified Anti-Human CD27 Antibody[O323] (Right) and 0.2 μg Mouse IgG1, κ Isotype Control (Left), followed by Alexa Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD19 PE-conjugated Monoclonal Antibody.

Human peripheral blood lymphocytes were stained with 0.2 μg Purified Anti-Human CD27 Antibody[O323] (Right) and 0.2 μg Mouse IgG1, κ Isotype Control (Left), followed by Alexa Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD19 PE-conjugated Monoclonal Antibody.

Catalog Number:MAB11400P
Size:100μg
Concentration:≥ 1 mg/mL
Host:Mouse
Isotype:Mouse IgG1, κ
Clone:O323
Immunogen:Recombinant Human CD27 protein
Reactivity:Human
Applications:FCM
Purification:>98%, Protein A/G purified

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

Applications

FCM

Immunogen

Recombinant Human CD27 protein

Target Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

Storage

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Buffer

PBS, pH 7.2. Contains 0.05% proclin 300.

Human peripheral blood lymphocytes were stained with 0.2 μg Purified Anti-Human CD27 Antibody[O323] (Right) and 0.2 μg Mouse IgG1, κ Isotype Control (Left), followed by Alexa Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD19 PE-conjugated Monoclonal Antibody.

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