Immunological Sciences

R-Spondin

Western Blot using AB-83545 on extracts of various cells.

Western Blot using AB-83545 on extracts of various cells.

Catalog Number:AB-83545
Conjugate:Unconjugated
Size:100 ug
Concentration:1mg/ml
Host:Rb
Isotype:IgG
Clone:POLY
Immunogen:Recombinant protein of Human R-Spondin 1
Reactivity:Hu, Ms, Rt
Applications:Western Blot: 1:1000 Immunohistochemistry: (Paraffin-embedded section): 1:100
Molecular Weight:28-29 KDa
Purification:Aff. Pur.
Form:Liquid

Applications

Western Blot: 1:1000 Immunohistochemistry: (Paraffin-embedded section): 1:100

Immunogen

Recombinant protein of Human R-Spondin 1

Target Background

This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants.

Storage

At + 4°C for short term, at-20°C for longer term. Avoid Freeze and Thaw cycles.

Buffer

PBS, with 0,02% sodium Azide, 50% glycerol, pH 7.3

Western Blot using AB-83545 on extracts of various cells.

IHC(P) 1:100 on Rat Lung using R Spondin

IHC (P) 1:100 on mouse lung

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